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商品详细免疫化学/乙酰赖氨酸抗体,HRP/100μg/ICP0381
免疫化学/乙酰赖氨酸抗体,HRP/100μg/ICP0381
免疫化学/乙酰赖氨酸抗体,HRP/100μg/ICP0381
商品编号: ICP0381
品牌: immunechem
市场价: ¥7900.00
美元价: 3950.00
产地: 美国(厂家直采)
公司:
产品分类: 蛋白酶类
公司分类: protease
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Acetyl Lysine Antibody, HRP

Catalog # Pack Size Price(USD)
ICP0381 100μg $395.00

Quantity:

Product Description
The rabbit anti-acetyl lysine antibody (anti-AcK) is developed using acetylated KLH as the immunogen. It is affinity purified with acetyl lysine agarose, followed by conjugation with horseradish peroxidase(HRP).
Western blot analysis of acetylated histone from TSA-treated (A) and non-treated (B) melanoma cells using ICP0381.
Species
Rabbit
Formulation
250 µg/mL in stabilizing buffer with 50% glycerol
Immunogen
Acetylated KLH conjugates
Purification
Affinity chromatography with acetyl-lysine agarose
Conjugation
Reductive amination; HRP:Ab molar ratio =10:1
Specificity
The antibody recognizes proteins acetylated on lysine residues. Tested: acetylated histone, acetylated BSA and acetylated MBP. No cross-reaction to the non-acetylated proteins.
Applications
For direct immunofluorescence experiments
Scientific Description
DNA transcription cannot take place unless DNA is unwound from the nucleosomes. The cell unwinds the DNA by acetylating the lysine residues within the proteins. It has been suggested that acetylation of non-histone proteins (e.g. transcription factors) and histones may be involved. Acetylation of the proteins may result in signal transduction within the chromatic domains.
Storage & Stability
Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is six months from date of shipping if stored properly.

Product Specific References

  1. 1. Curr. Opin. Chem. Biol.1997.1(3): 300-308.doi:10.1016/S1367-5931(97)80066-X.
  2. 2. Curr. Biol. 2002.12(4): R141-R143. doi:10.1016/S0960-9822(02)00709-1.
  3. 3. J. Cel. Rep. 2014.7(5): 1471-1480.doi:10.1016/j.celrep.2014.04.021.
  4. 4.Biosci. Rep.2017. BSR20170157.doi: 10.1042/BSR20170157
  5. 5. Bioscience Reports2017. 37(4): BSR20170157.doi:10.1042/BSR20170157.
  6. 6.Mol. Microbiol.2017. 103(5): 845-859.doi:10.1111/mmi.13595

品牌介绍
加拿大免疫化学药剂有限公司(ImmuneChem Pharmaceuticals Inc. 简称ICP) 是由加拿大政府资助而创立的生物高科技开发公司。始创立于1997年,公司的研究与开发部门位于加拿大不列颠斯哥伦比亚省大温哥华地区。ICP是一个以蛋白质化学技术和免疫技术为基础的免疫化学药物高科技公司。以固相表面化学技术为基础,以蛋白质分离提纯基础为核心,以免疫技术为应用,致力于开发科研和诊断用免疫球蛋白以及医疗用被动免疫球蛋白,其所创建的ImmuneChem品牌抗体试剂多年来畅销世界各地。